Title | Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB |
Journal | J Biol Chem |
Volume | 293 |
Issue | 6 |
Pagination | 2006-2014 |
Date Published | 2018 02 09 |
ISSN | 1083-351X |
Abstract | Although calorically equivalent to glucose, fructose appears to be more lipogenic, promoting dyslipidemia, fatty liver disease, cardiovascular disease, and diabetes. To better understand how fructose induces lipogenesis, we compared the effects of fructose and glucose on mammalian target of rapamycin complex 1 (mTORC1), which appeared to have both positive and negative effects on lipogenic gene expression. We found that fructose acutely and transiently suppressed mTORC1 signaling and The constitutive activation of mTORC1 reduced hepatic lipogenic gene expression and produced hypotriglyceridemia after 1 week of fructose feeding. In contrast, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress plasma triglycerides after 1 week of glucose feeding. Thus, these data reveal fundamental differences in the signaling pathways used by fructose and glucose to regulate lipid metabolism. |
DOI | 10.1074/jbc.M117.782557 |
Alternate Journal | J. Biol. Chem. |
PubMed ID | 29222328 |
PubMed Central ID | PMC5808762 |
Grant List | K99 DK100539 / DK / NIDDK NIH HHS / United States R56 DK056123 / DK / NIDDK NIH HHS / United States R01 DK056123 / DK / NIDDK NIH HHS / United States R00 DK100539 / DK / NIDDK NIH HHS / United States R01 DK094162 / DK / NIDDK NIH HHS / United States |