Submitted by kebloom on January 16, 2019 - 3:41pm
Title | Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Flamant F, Cheng S-Y, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S |
Journal | Endocrinology |
Volume | 158 |
Issue | 7 |
Pagination | 2052-2057 |
Date Published | 2017 07 01 |
ISSN | 1945-7170 |
Keywords | Animals, DNA, Humans, Receptors, Thyroid Hormone, Signal Transduction, Terminology as Topic, Thyroid Hormones, Transcription Factors |
Abstract | Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed. |
DOI | 10.1210/en.2017-00250 |
Alternate Journal | Endocrinology |
PubMed ID | 28472304 |
PubMed Central ID | PMC6283428 |